Fielding first, Kings XI Punjab skipper opened with legspinner Karanveer Singh and he started well conceding just four runs off his first over before he was hammered for 22 in his second by Dwayne Smith.
Riding on Smith's blazing start CSK raced to 50 in just 4.3 overs before the West Indian was removed by Anureet Singh.
After missing Kings XI Punjab's previous game owing to a shoulder injury, George Bailey was back in the playing XI at the expense misfiring Glenn Maxwell. MS Dhoni, however, won the toss and elected to bat first.
Both teams observed a two-minute silence before the start of the match for the earthquake victims of Nepal.
Suresh Raina got two reprieves during his innings. The first one was when he was on eight as the umpire failed to hear a edge off Sandeep Sharma taken by wicketkeeper Wriddhiman Saha. The second came when he was on 14 as Mitchell Johnson grassed a simple chance deep midwicket.
After being dropped on 23 by Mitchell Johnson, Brendon McCullum capitalised on the reprieve scoring his fifty just 32 balls.
McCullum combined with Suresh Raina for a fifty run stand before he was caught at long-off by David Miller off Axar Patel for 66 (44 balls, 8x4, 3x6).
However, luck did not favour Raina the third time as the left-handed batsman backed up too far only to be run-out at the non-striker's end to for 29.
Last-match hero Shaun Marsh departed early for 10 and Kings XI Punjab couldn't recover from there. In their reply, they could only manage 95 for 9 and suffered their fourth defeat in six matches.