Steven Finn picked up two early wickets to become the third fastest England bowler to 100 ODI wickets.
Kraigg Brathwaite tried to steady the innings even as he saw Shai Hope depart after a promising start.
Jason Mohammed and Kraigg Brathwaite put on a half-century stand to stabilize West Indies' innings.
Moeen Ali ended the partnership by having Kraigg Brathwaite out stumped.
Liam Plunkett picked up quick wickets in the latter stage of the innings to hurt West Indies.
Adil Rashid also got amongst the wickets as West Indies were bowled out for 225.
Shannon Gabriel struck early to dismiss Sam Billings.
Jason Roy hit a flurry of boundaries, going past fifty in quick time and putting on a good stand with Joe Root to help England forward in the chase.
Ashley Nurse led West Indies' fight back with quick wickets.
Joe Root went past fifty while wickets were falling at the other end.
Devendra Bishoo also came to the party to leave England reeling.
A superb half-century from Chris Woakes put England back on track.
Joe Root hit an unbeaten 90 and put on a crucial 102-run stand for the seventh wicket with Chris Woakes (68*) to help England win by four wickets and seal the series.