Sarfaraz Ahmed scored an unbeaten 32-ball 46, stroking five boundaries.
Having laid a good foundation, Shoaib Malik (left) and Sarfaraz Ahmed paced Pakistan's innings brilliantly to take them to 160 for 4 in 20 overs.
West Indies struck early after they won the toss and elected to field. Samuel Badree (right) managed to bowl Sharjeel Khan.
Babar Azam (right) and Khalid Latif resurrected Pakistan's innings with their second consecutive half century stand for the second wicket. They put on 54 runs before Azam was dismissed.
Sunil Narine and Jerome Taylor hit some big shots towards the end. However, their efforts proved too less and came too late to help West Indies' cause.
West Indies' chase got off on a disastrous note yet again as they were reduced to 19 for 3 in 4.3 overs.
Sohail Tanvir used his variations cleverly and bagged three wickets. The left-arm pacer conceded only 13 runs off his four overs.
Pakistan bowlers kept picking up wickets at regular intervals to never let the initiative slip away.
Pakistan won the second T20I by 16 runs and sealed the three-match series 2-0.